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Why Research Sites Are Switching to Connected eISF and CTMS

Increasingly, research sites are not just asking how to digitize document management, but how to connect their document management system to the rest of their clinical operations without adding operational burden. The growing adoption of Advarra’s eReg—a secure, paperless electronic Investigator Site File (eISF) system integrated with OnCore and Clinical Conductor, the most widely used clinical trial management systems (CTMSs) among research sites—reflects the shift toward integrated technology that enhances operational visibility and supports long-term scalability.      

A Practical Checklist for Building Confidence in Site Selection

How operational insight, performance data, and patient access signals can strengthen clinical trial site decisions …

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Sponsor’s Guide to IRB Approval (Part VI): After IRB Approval: Compliance, Multi-Site Oversight, and Turning Review into a Strategic Advantage 

IRB approval is a critical milestone in clinical research, but it isn’t the end of the oversight…

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Do DSMBs Need AI Expertise?

Rethinking oversight as clinical trials become more data-driven and algorithm-informed  As artificial intelligence (AI) becomes…

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What Protocol Amendments Reveal About Trial Design

Key takeaways from ‘The Operational Realities of Protocol Amendments’ panel discussion at the Advarra Innovation…

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Q&A with Advarra’s Manager of Ongoing Review MaryJo Carter 

MaryJo Carter has spent more than nine years at Advarra, growing alongside the organization and helping shape…

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Sponsor’s Guide to IRB Approval (Part V): How to Speed Up IRB Approvals 

Institutional review board (IRB) approval is a critical milestone in clinical research, but it can…

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Data Safety Monitoring Boards (DSMBs) in the Era of AI and Adaptive Clinical Trials

Balancing innovation, statistical rigor, and independent oversight in increasingly complex clinical trials  Clinical trials are…

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Why Should Local IRBs and HRPPs Collaborate with External IRBs? 

Multisite research and clinical trials increasingly rely on a single IRB (sIRB) for review. This increase reflects federal mandates, sponsor expectations,…

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Sponsor’s Guide to IRB Approval (Part IV): Preparing IRB Documents That Prevent Delays

A strong protocol and well-drafted consent form are essential, but they are not enough on…

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Q&A with Advarra’s Associate Director of Client Success Evan Sander

Evan Sander knows firsthand that clinical research is never just about processes or paperwork—it’s about…

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Does mRNA Require IBC Review? How the NIH Guidelines Apply to Clinical Trials

Let me start with a question I get more and more frequently from research sites…

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Sponsor’s Guide to IRB Approval (Part III): Building an IRB-Ready Informed Consent

For sponsors, informed consent is one of the most visible signals of study quality during…

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