Join Advarra

Learn more about our company team, careers, and values. Join Advarra’s Talented team to take on engaging work in a dynamic environment.

See Jobs

Independent Review Committees for Safety and Compliance

Clinical research involving human participants typically involves some type of risk. Incorporating the appropriate ethics reviews and safety oversight helps ensure stakeholder safety, data integrity, and regulatory compliance.

Safety and Compliance Reviews

Independent Clinical Trial Safety Oversight

Independence is key to ensuring a committee’s review is unbiased and not influenced by those involved in study conduct.

Few would argue over the importance of IRB review being independent of study priorities, as this allows reviewers to focus solely on participant protections.

Independence also removes the potential for perceived bias, making the review more trustworthy in the eyes of regulators and the public.

It’s similarly critical for other research review committees, like DSMBs and endpoint adjudication committees, to be completely independent of those sponsoring or conducting the study.

Tips for More Efficient Research Reviews

  • Communicate your timelines and special requirements to the committee(s) as early as possible
  • Work with a single partner who can provide all of the reviews your study requires
  • Avoid extended follow-up questions by ensuring you provide all necessary materials in your initial submission
  • Communicate your timelines and special requirements to the committee(s) as early as possible
  • Ask questions and provide clarifications to ensure the committee understands your position
  • Use the committee’s tracking platform or other available technology to stay informed on review activities (and consider integrating your trial technology with the committee’s)
  • Request study metrics to understand bottlenecks with the committee and within your organization
  • Utilize platforms like SMART IRB to streamline reliance agreement activities

Extensive Reach and Trusted Expertise


institutions, academic medical centers, and hospital systems supported by Advarra’s IRB – more than any other IRB


sites worldwide registered with Advarra’s IBC – more than any other IBC


biostatisticians, medical experts, and clinical professionals globally supporting Advarra’s DSMB and EAC


Advarra’s reviews support 100% of:

  • Top 50 global biopharma sponsors

  • Top 20 CROs

  • NCI-designated cancer centers

Comprehensive Review Solutions for Every Need

Read our Related Resources


Clinical Endpoint Adjudication Committees: Not Just for “Endpoints”

This blog outlines critical events where EACs are used to look at more than just “endpoints” in clinical research.

Read Now
4 min. read
Read more
White Paper

Reporting to the IRB: What Does and Does Not Need to be Reported

This white paper outlines IRB reporting requirements, why reporting is important, and what should and should not be reported.

Read Now
Read more

Does This Study Require IBC Review?

While clinical research professionals are familiar with the role of the IRB to protect research subjects, most are unfamiliar with the added need for an Institutional Biosafety Committee (IBC).

Read Now
4 min. read
Read more

Visit the Resource Library

Ready to get started? Contact us about your next study.

Contact Us