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Independent Review Committee Solutions to Protect Participants and Optimize Research Performance

Safeguard participants, research staff, and the community with truly integrated, expert review solutions designed to streamline study conduct.

Your Trusted Partner for Independent Research Oversight


Institutional review board (IRB)

Rely on the research community’s preferred independent IRB when conducting efficient, responsible research regardless of project scope, therapeutic niche, or number of investigators.

Over 3,500 institutions, academic medical centers, and hospitals rely on Advarra’s IRB.


Institutional biosafety committee (IBC)

Advance your research by leveraging the world’s largest integrated IRB and IBC service, combined with the most comprehensive Gene Therapy Ready site network.

Advarra provides comprehensive review and oversight of clinical trials involving investigational products containing engineered genetic material.


Data monitoring committee (DMC) / data safety monitoring board (DSMB)

Ensure independent, knowledgeable oversight of interim clinical trial data with a worldwide network of experienced biostatistical and medical professionals.

Advarra has deep expertise in all therapeutic areas, trial designs, and complex biostatistical endpoints.


Endpoint adjudication committee (EAC) / clinical event committee (CEC)

Secure independent evaluation and adjudication of complex clinical drug and device trial endpoints worldwide.

Whether you need assessment from one medical expert or an EAC/CEC, Advarra’s experts understand the various comorbidities and confounding variables present in complex clinical trials.

Expertise for Every Study


Every Phase and Type

Each clinical trial phase has its own unique challenges and needs. Device, social behavioral, and post marketing studies have their own dynamics. Advarra has experience with all trial phases, and our IRB roster includes unique expertise in early phase, device, and minimal risk research.

Every Specialty

Work with research compliance professionals who understand the latest clinical developments, regulatory requirements, and research innovations. From genetic engineering and gene therapy, to oncology basket studies and decentralized trial modalities, Advarra draws upon a broad network of experts to ensure robust oversight.

Every Review

Ensure comprehensive, truly independent ethical and safety oversight with a full suite of review services: IRB, IBC, DMC/DSMB, and EAC/CEC. Advarra is the largest integrated independent research oversight services organization.

Read our Related Resources


James Riddle and Barbara Schneider Delve into the Different Players Involved in Reviewing Clinical Research

In this podcast episode, we discuss the different clinical research oversight committees and functions to ensure the safety of participants.

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IBC Overview eLearning Module

Institutional biosafety committee oversight is necessary to ensure the safety of those involved in research with engineered genetic materials.

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White Paper

What Level of Review Does Your Study Need?

In this infographic, we share useful information for investigators to know which level of IRB review likely applies to their study.

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