An Investigative Site Network (ISN) is a coordinated group of clinical trial sites operating under shared governance, standard procedures, and performance expectations.
ISNs often centralize feasibility, contracting, startup activities, and operational oversight to reduce variability across sites. Standardized training and consistent workflows improve protocol adherence, data quality, and participant experience. Sponsors use ISNs to scale enrollment efficiently while maintaining quality management and monitoring standards. Well-run networks can improve timeline predictability and support inspection readiness through uniform documentation practices.