An Electronic Protocol Review Management System (ePRMS) is a digital workflow platform used to submit, review, track, and document protocol approvals and amendments.
ePRMS systems support structured routing, reviewer comments, decision documentation, and controlled recordkeeping for oversight activities. They improve efficiency by reducing manual handoffs and enabling real-time visibility into review status and outstanding requirements. In regulated research, ePRMS platforms must be secure, validated, and capable of maintaining audit trails. Robust ePRMS use strengthens traceability, consistency, and inspection readiness for protocol oversight records.