The Office for Human Research Protections (OHRP) oversees compliance with federal regulations protecting human research participants.
OHRP administers the Common Rule (45 CFR 46) and reviews institutional assurances and IRB performance. Institutions must maintain policies aligned with OHRP guidance to conduct federally supported research. OHRP investigations address noncompliance, informed consent issues, and reporting failures. Alignment with OHRP standards supports ethical research conduct and participant protections.