A Protocol Review and Monitoring Committee (PRMC) is an oversight committeeócommon in oncology and academic settingsóthat evaluates clinical trial protocols for scientific merit, feasibility, safety, and resource impact.
PRMC review typically occurs in addition to IRB review, with emphasis on whether the study design can answer the research question and whether monitoring plans are adequate for participant risk. PRMCs may assess endpoint selection, eligibility criteria, statistical rigor, and accrual feasibility to reduce avoidable trial failure and participant exposure to low-value research. In cancer centers, PRMC oversight helps align trials with institutional priorities and shared resource capacity. Documented PRMC decisions support governance transparency and strengthen the overall quality framework for investigator-initiated and sponsored studies.