A Scientific Review Committee (SRC) is a group that reviews research proposals for scientific quality, feasibility, and alignment with institutional standards.
SRC review often focuses on study design rigor, endpoint appropriateness, recruitment feasibility, and resource justification. Many cancer centers use SRCs to ensure protocols meet internal scientific standards before IRB submission. SRC recommendations can reduce amendments and improve operational clarity by addressing design weaknesses early. Strong SRC oversight supports ethical conduct by ensuring risks are justified by meaningful scientific value.