System Organ Class (SOC) is the highest level of the MedDRA hierarchy used to group adverse events by body system or clinical category.
SOC groupings help summarize safety results in tables, listings, and narratives by organizing coded terms into clinically meaningful buckets. Safety analyses often present adverse events by SOC and Preferred Term to support transparent interpretation of risk patterns. Consistent coding and SOC assignment are essential for cross-study comparisons, signal detection, and regulatory reporting. SOC-based summaries are a common feature of clinical study reports and integrated safety analyses.