The WHO Global Vaccine Safety Initiative (GVSI) is a World Health Organization program designed to strengthen vaccine safety surveillance and safety science worldwide.
GVSI promotes capacity building, harmonized approaches to monitoring, and best practices for investigating vaccine safety signals. In vaccine trials, GVSI perspectives can inform safety monitoring plans, event definitions, and risk communication approachesóespecially for multinational studies. Guidance supports consistent safety thinking across regions and strengthens the quality of safety evidence. Its global frameworks complement domestic oversight by adding international signal detection and surveillance context.