Absorption, Distribution, Metabolism, and Elimination (ADME) describes the four primary pharmacokinetic processes that determine how a drug behaves in the body.
ADME data characterize how quickly and efficiently a compound enters systemic circulation, reaches target tissues, is biotransformed, and is cleared. These parameters are critical for dose selection, safety margin calculations, and first-in-human study design. ADME findings also identify potential drugñdrug interactions and metabolic liabilities. Robust ADME evaluation supports regulatory submissions and riskñbenefit assessments throughout development.