The Common Terminology Criteria for Adverse Events (CTCAE) is a standardized system used to classify and grade adverse event severity in clinical trials.
CTCAE provides consistent terms and grading scales that support comparable safety reporting across sites and sponsors. It is widely used in oncology trials and other therapeutic areas requiring detailed toxicity characterization. Standardized grading improves safety signal detection and benefitñrisk evaluation. CTCAE outputs support oversight by safety committees, regulators, and ethics review bodies.