An Endpoint Adjudication Committee (EAC) is an independent group that reviews and validates clinical trial endpoints using predefined criteria to ensure consistent outcome determination.
EACs are often used when endpoints are complex, subjective, or dependent on imaging, clinical events, or diagnostic interpretation. Independent adjudication reduces bias and variability across study sites and investigators. This process improves data consistency and strengthens confidence in primary and secondary endpoint results. Regulators often view adjudicated endpoints as more reliable for benefitñrisk assessment.