Prescription-Only Medicine (POM) is a classification for medications that require a licensed prescriber authorization rather than over-the-counter access.
In research settings, POM status affects dispensing controls, accountability procedures, and participant instructions to ensure appropriate use. Protocols must define how POMs are obtained, administered, and documented, particularly when used as background therapy or comparator treatment. POM classification also influences drugñdrug interaction assessments and safety monitoring requirements. Clear handling procedures support medication safety, compliance, and reliable outcome interpretation.