A Protocol Review and Monitoring System (PRMS) is an operational workflow and recordkeeping framework used to track protocol review, approvals, monitoring activities, and compliance status over time.
PRMS may be implemented as a formal institutional process or a technology-enabled system that captures review outcomes, committee actions, reporting milestones, and required follow-up. By centralizing protocol oversight data, PRMS supports consistent governance, improved traceability, and faster identification of overdue reviews or monitoring gaps. Institutions use PRMS reporting to demonstrate ongoing oversight to leadership, auditors, and external stakeholders such as funders. A well-run PRMS strengthens inspection readiness by showing that protocol oversight is systematic, documented, and continuously maintained.