The Global Advisory Committee on Vaccine Safety (GACVS) is a World Health Organization advisory body that provides independent scientific review and guidance on vaccine safety issues.
GACVS evaluates global safety data and emerging risk signals to inform vaccine safety communications and monitoring priorities. In vaccine clinical trials, its conclusions can influence safety monitoring strategies, endpoint selection, and riskñbenefit framing. Although not a U.S. regulator, GACVS recommendations provide internationally recognized perspectives that complement domestic oversight. Sponsors may reference GACVS outputs to align global safety narratives and strengthen pharmacovigilance planning.