A Nonsteroidal Anti-Inflammatory Drug (NSAID) is a class of medications used to reduce inflammation, pain, and fever by inhibiting cyclooxygenase enzymes.
NSAIDs are commonly used as concomitant medications or comparators in clinical trials and may influence safety outcomes such as gastrointestinal or cardiovascular events. Protocols must clearly define NSAID use to avoid confounding efficacy or safety assessments. Accurate documentation of NSAID exposure supports pharmacovigilance and causality evaluation. Careful monitoring ensures participant safety and reliable interpretation of study results.